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Management
Christian Rohlff, PhD
CEO / founder
Dr. Rohlff received his Ph.D. from the Department of Pharmacology at Georgetown
University in 1994. After two appointments at the National Cancer Institute he
joined Oxford GlycoSciences and was appointed Director of Proteome Research
Collaborations in 2001. As manager of the Proteomics Division's commercial
collaborations he gained expertise in the implementation of clinical proteomics
programmes to identify novel therapeutic protein targets and protein biomarkers
with many pharmaceutical companies and academic partners, including Pfizer, GSK,
Bayer, Wyeth, Takeda, the Cystic Fibrosis Foundation, Oxford University and the
FDA. These studies have investigated many disease areas including Alzheimer's
disease, arteriosclerosis, dermal ulcers, asthma, chronic obstructive pulmonary
disease, various metabolic, inflammatory and neuropsychiatric disorders,
toxicology, and oncology. Dr Rohlff co-authored over 20 protein patents
originating from these studies. Dr. Rohlff is the founder of Oxford BioTherapeutics.
Jim Cornett, PhD
Chief Operating Officer
Jim Cornett received his PhD in molecular biology at the University of Arizona Medical School and completed post-doctoral
studies at Temple University Medical School in Philadelphia. In 1978, Jim joined Sterling Drug and led basic research
and project teams for new antimicrobial agents from research through the IND stage of development. In 1986 Jim joined
the clinical research department at Centocor as an Assistant Director, beginning a more than twenty year career with
monoclonal antibodies as therapeutic agents. While at Centocor, Jim contributed to multiple areas including clinical
research, regulatory affairs, project management and technology transfer to commercial partners in Japan. Jim joined
Protein Design Labs in 1993 as Director of Business Development where he focused on global licensing of antibody-related
technologies including antibody humanization. In 2000, he joined his third antibody company, Medarex, as Vice President,
Business Development. His work led to the establishment of numerous licensing and collaborative R&D relationships in the
area of fully human antibody therapeutics with both biotech and global pharmaceutical companies. In addition to his role
as COO, Jim is President of the company’s US subsidiary, Oxford BioTherapeutics Inc.
Jon Terrett, PhD
Chief Scientific Officer
Jon Terrett completed his PhD and postdoctoral work in human genetics at Nottingham in 1996 after which he moved to Smithkline
Beecham to establish the pharmacogenetics and DNA microarray laboratories. In 1999 he moved to Oxford Glycosciences (OGS) as
Director of Molecular Oncology and spent the next 5 years building the Oncology MAb target discovery program. This platform
fed multiple antibody companies with targets, the most successful collaboration being with Medarex where many lead drug candidates
were selected and tested in vivo. Following Celltech’s acquisition of OGS, Dr Terrett moved to Medarex (USA) in 2004 to complete
the work developing the drugs discovered via the proteomics platform and progressed two into phase1 clinical trials and many
others through preclinical proof of concept. Jon is based at the company’s US subsidiary, near San Jose, CA.
Mike Gresser, PhD
Senior Vice President, Cancer Stem Cell Therapeutics
Mike Gresser received his Ph.D in Biochemistry in 1976 and after postdoctoral studies at the Molecular Biology Institute at
UCLA he joined the Department of Chemistry at Simon Fraser University in Burnaby, British Columbia. In 1988 Mike Joined
the Merck Frosst Center for Therapeutic Research in Kirkland, Quebec as Director of Biochemistry. Over the next twelve
years Mike progressed to Executive Director of Biochemistry and Molecular Biology and his team worked on a variety of small
molecule drug discovery programs, resulting in the introduction of numerous molecules into clinical trials. Two of these
molecules, Singulair and Vioxx, became products. In 2000 Mike joined Amgen Inc. in Thousand Oaks, California, as Vice
President Research for Inflammation, where he remained until April, 2006. Mike’s team at Amgen worked on many molecular
targets, introducing numerous small molecules, human antibodies, and other proteins into development. Currently Mike is
also Visiting Scholar at the Molecular Biology Institute at UCLA.
Tom Boone
Senior Vice President, Protein Sciences
Tom is an experienced bench scientist and manager having served a 28 year career with Amgen. Tom started as a research associate
cDNA cloning and sequencing genes including G-CSF (Neupogen). During the late 80’s and throughout the 1990’s Tom worked in process
development as a scientist and director and developed or oversaw the development of many of the processes implemented at Amgen
including the Neupogen process.
Tom headed the expression, purification, and characterization groups within Amgen's research group which went on to become
the Protein Science group. Over the years other support research groups and protein science groups from other sites have been
added and created.
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